Centro Andaluz de Biología Molecular y Medicina Regenerativa
Selected publications in 2020:

  1. Alba G, Martínez R, Postigo-Corrales F, López S, Santa-María C, Jiménez J, Cahuana GM, Soria B, Bedoya FJ, Tejedo JR. 2020. AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3-beta, and beta-Catenin. ACS Omega. 5(32):20270-20282.

  2. Alonso-de Vega I, Paz-Cabrera MC, Rother MB, Wiegant WW, Checa-Rodríguez C, Hernández-Fernaud JR, Huertas P, Freire R, van Attikum H, Smits VAJ. 2020. PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks. Nucleic Acids Res. 48(9):4915-4927.

  3. Álvarez-Quilón A, Terrón-Bautista J, Delgado-Sainz I, Serrano-Benítez A, Romero-Granados R, Martínez-García PM, Jimeno-González S, Bernal-Lozano C, Quintero C, García-Quintanilla L, Cortés-Ledesma F. 2020. Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency. Nat Commun. 11(1):910.

  4. Baghi M, Rostamian Delavar M, Yadegari E, Peymani M, Pozo D, Hossein Nasr-Esfahani M, Ghaedi K. 2020. Modified level of miR-376a is associated with Parkinson's disease. J Cell Mol Med. 24(4):2622-2634.

  5. Baratto-Roldán A, Jiménez-Ramos MDC, Jimeno S, Huertas P, García-López J, Gallardo MI, Cortés-Giraldo MA, Espino JM. 2020. Preparation of a radiobiology beam line at the 18 MeV proton cyclotron facility at CNA. Phys Med. 74:19-29.

  6. Berná G, Romero-Gomez M. 2020. The role of nutrition in non-alcoholic fatty liver disease: Pathophysiology and management. Liver Int. 40 Suppl 1:102-108. doi: 10.1111/liv.14360.

  7. Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R. 2020. Epicardial cell lineages and the origin of the coronary endothelium. FASEB J. 34(4):5223-5239.

  8. Checa-Rodríguez C, Cepeda-García C, Ramón J, López-Saavedra A, Balestra FR, Domínguez-Sánchez MS, Gómez-Cabello D, Huertas P. 2020. Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination. DNA Repair (Amst). 94:102902. doi: 10.1016/j.dnarep.2020.

  9. de Breuk A, Acar IE, Kersten E, Schijvenaars MMVAP, Colijn JM, Haer-Wigman L, Bakker B, de Jong S, Meester-Smoor MA, Verzijden T, Missotten TOAR, Monés J, Biarnés M, Pauleikhoff D, Hense HW, Silva R, Nunes S, Melo JB, Fauser S, Hoyng CB, Ueffing M, Coenen MJH, Klaver CCW, den Hollander AI; EYE-RISK Consortium. 2020. Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium. Ophthalmology. S0161-6420(20)30725-9.

  10. Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. 2020. NQO1 protects obese mice through improvements in glucose and lipid metabolism. NPJ Aging Mech Dis. 6(1):13.

  11. Esmaeili M, Keshani M, Vakilian M, Esmaeili M, Peymani M, Seyed Forootan F, Lan Chau T, Ismail Göktuna S, Rasoul Zaker S, Hossein Nasr Esfahani M, Ghaedi K. 2020. Role of Non-Coding RNAs as Novel Biomarkers for Detection of Colorectal Cancer Progression Through Interaction With the Cell Signaling Pathways. GENE. 44796. doi: 10.1016/j.gene.2020.144796.

  12. Gauthier BR, Sola-García A, Cáliz-Molina MÁ, Lorenzo PI, Cobo-Vuilleumier N, Capilla-González V, Martin-Montalvo A. 2020. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 19(11):e13260.

  13. Gianini M, Bayona-Feliu A, Sproviero D, Barroso SI, Cereda C, Aguilera A. 2020. TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage. Plos Genetics. 16(12):e1009260.

  14. Gómez-González B, Aguilera A. 2020. Looping the (R) Loop in DSB Repair via RNA Methylation. Mol Cell. 79(3):361-362.

  15. Gómez-González B, Barroso S, Herrera-Moyano E, Aguilera A. 2020. Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle. Cell Cycle. 19(5):525-531.

  16. Gómez-González B, Ortega P, Aguilera A. 2020. Histone deacetylases facilitate the accurate repair of broken forks. Mol Cel Oncology. 7(2):1705731.

  17. Gonzalez-Moro I, Olazagoitia-Garmendia A, Colli ML, Cobo-Vuilleumier N, Postler TS, Marselli L, Marchetti P, Ghosh S, Gauthier BR, Eizirik DL, Castellanos-Rubio A, Santin I. 2020. The T1D-associated lncRNA Lnc13 modulates human pancreatic beta cell inflammation by allele-specific stabilization of STAT1 mRNA. Proc Natl Acad Sci USA. 117(16):9022-9031.

  18. Guerrero-Martínez JA, Ceballos-Chávez M, Koehler F, Peiró S, Reyes JC. 2020. TGFB promotes widespread enhancer chromatin opening and operates on genomic regulatory domains. Nature Communications. 11(1):6196.

  19. Hmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. 2020. Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. Front Bioeng Biotechnol. 8:43.

  20. Lafuente-Barquero J, García-Rubio ML, Martin-Alonso MS, Gómez-González B, Aguilera A. 2020. Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner. Elife. 9:e56674.

  21. López-Beas J, Guadix JA, Clares B, Soriano-Ruiz JL, Zugaza JL, Gálvez-Martín P. 2020. An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient. Med Res Rev. 40(4):1315-1334 .

  22. Luna R, Rondón AG, Pérez-Calero C, Salas-Armenteros I, Aguilera A. 2020. The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops. Cold Spring Harb Symp Quant Biol. 84:105-114 .

  23. Mahmud MRA, Ishii K, Lozano CB, Sainz ID, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H. 2020. TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. Genes Cells. 25(7):450-465 .

  24. Manzano-López J, Monje-Casas F. 2020. Asymmetric cell division and replicative aging: a new perspective from the spindle poles. Curr Genet. 66(4):719-727 .

  25. Manzano-López J, Monje-Casas F. 2020. The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control. Int J Mol Sci. 21(3). pii: E709.

  26. Matellán L, Manzano-López J, Monje-Casas F. 2020. Polo-like kinase acts as a molecular timer that safeguards the asymmetric fate of spindle microtubule-organizing centers. Elife. 9:e61488.

  27. Matellán L, Monje-Casas F. 2020. Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae. GENES. 11(2). pii: E195.

  28. Mejías-Navarro F, Rodríguez-Real G, Ramón J, Camarillo R, Huertas P. 2020. ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection. PLoS Genet. 16(5):e1008787.

  29. Moreno-Oñate M, Herrero-Ruiz AM, García-Dominguez M, Cortés-Ledesma F, Ruiz JF. 2020. RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair. J Mol Biol. 432(13):3965-3979 .

  30. Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. 2020. A Genetic Map of the Response to DNA Damage in Human Cells. CELL. 182(2):481-496.

  31. Ortega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. 2020. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 7(7):190-198.

  32. Pardo, Benjamin; Moriel-Carretero, Maria; Vicat, Thibaud; Aguilera, Andres; Pasero, Philippe. 2020. Homologous recombination and Mus81 promote replication completion in response to replication fork blockage. EMBO reports. 21(7):e49367 .

  33. Peña-Gómez MJ, Rosado IV, Balestra FR, Huertas P, López-Cornejo P. 2020. Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material. Pharmaceutics. 12(5):E482.

  34. Peñate X, Praena-Fernández JM, Romero Pareja P, Enguix-Riego MDV, Payán-Bravo L, Vieites B, Gomez-Izquierdo L, Jaen Olasolo J, Rivin Del Campo E, Reyes JC, Chávez S, Lopez Guerra JL. 2020. Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers (Basel). 12(4). pii: E1052.

  35. Pérez-Calero C, Bayona-Feliu A, Xue X, Barroso SI, Muñoz S, González-Basallote VM, Sung P, Aguilera A. 2020. UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide. Genes Dev. 34(13-14):898-912 .

  36. Pozo D. 2020. Cell-based drug delivery harnesses inflammatory and autoimmune responses in neurodegeneration. J Mol Med (Berl). Ahead of print .

  37. Rincón AM, Monje-Casas F. 2020. A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division. Cell Cycle. 19(12):1405-1421 .

  38. Rivero S, Rodríguez-Real G, Marín I, Huertas P. 2020. MRGBP, a member of the NuA4 complex, inhibits DNA double strand break repair. FEBS Open Bio. Epub ahead of print.

  39. Rodríguez-Seguel E, Villamayor L, Arroyo N, De Andrés MP, Real FX, Martín F, Cano DA, Rojas A. 2020. Loss of GATA4 causes ectopic pancreas in the stomach. J Pathol. 26(1):1.

  40. Romero-Zerbo SY, García-Fernández M, Espinosa-Jiménez V, Pozo-Morales M, Escamilla-Sánchez A, Sánchez-Salido L, Lara E, Cobo-Vuilleumier N, Rafacho A, Olveira G, Rojo-Martínez G, Gauthier BR, González-Mariscal I, Bermúdez-Silva FJ. 2020. The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease. Front Endocrinol (Lausanne). 11:103.

  41. Salto R, Girón MD, Manzano M, Martín MJ, Vílchez JD, Bueno-Vargas P, Cabrera E, Pérez-Alegre M, Andujar E, Rueda R, Lopez-Pedrosa JM. 2020. Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy. Nutrients. 12(2).

  42. Santamaría-Hernando S, Cerna-Vargas JP, Martínez-García PM, de Francisco-de Polanco S, Nebreda S, Rodríguez-Palenzuela P, Rodríguez-Herva JJ, López-Solanilla E. 2020. Blue-light perception by epiphytic Pseudomonas syringae drives chemoreceptor expression, enabling efficient plant infection. Mol Plant Pathol. 21(12):1606-1619.

  43. Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS. 2020. Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res. 48(11):6310-6325 .

  44. Serrano-Benítez A, Cortés-Ledesma F, Ruiz JF. 2020. An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process. Front Mol Biosci. 6:153.

  45. Smani T, Mayoral-Gonzalez I, Galeano-Otero I, Gallardo-Castillo I, Rosado JA, Ordoñez A, Hmadcha A. 2020. Non-coding RNAs and Ischemic Cardiovascular Diseases. Adv Exp Med Biol. 1229:259-271.

  46. Solaguren-Beascoa M, Bujakowska KM, Méjécase C, Emmenegger L, Orhan E, Neuillé M, Mohand-Saïd S, Condroyer C, Lancelot ME, Michiels C, Demontant V, Antonio A, Letexier M, Saraiva JP, Lonjou C, Carpentier W, Léveillard T, Pierce EA, Dollfus H, Sahel JA, Bhattacharya SS, Audo I, Zeitz C. 2020. . Clin Genet. Ahead of Print.

  47. Soulet F, Bodineau C, Hooks KB, Descarpentrie J, Alves I, Dubreuil M, Mouchard A, Eugenie M, Hoepffner JL, López JJ, Rosado JA, Soubeyran I, Tomé M, Durán RV, Nikolski M, Villoutreix BO, Evrard S, Siegfried G, Khatib AM. 2020. ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation. JCI Insight. 5(14):129070.

  48. Vanhaeren T, Divina F, García-Torres M, Gómez-Vela F, Vanhoof W, Martínez-García PM. 2020. A Comparative Study of Supervised Machine Learning Algorithms for the Prediction of Long-Range Chromatin Interactions. Genes (BASEL). 11(9). pii: E985.

  49. Vítor AC, Huertas P, Legube G, de Almeida SF. 2020. Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox. Front Mol Biosci. 7:24.

  50. Vuilleumier NC, Gauthier BR. 2020. Time for a paradigm shift in treating type 1 diabetes mellitus: coupling inflammation to islet Regeneration. Metabolism. 104:154137.

  51. Wagner T, Pérez-Martínez L, Schellhaas R, Barrientos-Moreno M, Öztürk M, Prado F, Butter F, Luke B. 2020. . Plos Genetics. Epub ahead of print.