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eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Nature Communications. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.
Pablo Huertas
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 16 June 2023
Seminario
Martiijn Luijsterburg – Molecular mechanisms in transcription-coupled DNA repair - 30 June 2023
Seminario
Malu Martínez-Chantar – The importance of Post-translational control in liver disease
