Research Groups
Selected Publications
Nat Commun BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Nucleic Acids Res EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.
Nucleic Acids Res Rat1 promotes premature transcription termination at R-loops.
Cell Rep Evolutionary analysis of gene ages across TADs associates chromatin topology with whole-genome duplications.
Staff
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
Seminars
The schedule of Cabimer's 2024-2025 seminars will be published in September, but you can see here the list of this year's seminars.
