Research Groups
Core Facilities
News
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Selected Publications
PLoS Biol Characterization of a novel interaction of the Nup159 nucleoporin with asymmetrically localized spindle pole body proteins and its link with autophagy
Sci Adv SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome
Proc Natl Acad Sci U S A MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
Cell Rep Parental histone distribution and location of the replication obstacle at nascent strands control homologous recombination.
Staff
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
Seminars
- 06 October 2023
Seminario
Corrado Santocanale – Blocking DNA synthesis at origins and at forks: insights into CDC7 kinase targeting drugs using functional genomics approaches - 19 October 2023
Seminario
Karlene Cimprich – Causes and Consequences of Replication Stress - 27 October 2023
Seminario
Ulrich Rass – Disease-associated nuclease-helicase DNA2 is an essential gatekeeper to recombination at stalled DNA replication forks from yeast to human
