Centro Andaluz de Biología Molecular y Medicina Regenerativa
Selected Publications
Nat Commun Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation.
Nat Commun The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts.
Mol Cell DICER ribonuclease removes harmful R-loops.
EMBO Rep Break-induced RNA-DNA hybrids (BIRDHs) in homologous recombination: friend or foe?.
EMBO Rep Centriolar subdistal appendages promote double-strand break repair through homologous recombination.

Cintia Roodveldt

Misfolding proteins, molecular chaperones and immune dysregulation in neurodegenerative disease

Protein misfolding diseases, e.g. Parkinson’s, Alzheimer’s and ALS, are incurable neurodegenerative disorders characterized by the aberrant aggregation of specific proteins in the brain or CNS, leading to neuron death. Even the pathogenic mechanisms are still poorly understood, dysregulated immune responses are thought to play a major role. The aim of  our research is to elucidate the roles and molecular mechanisms of misfolding proteins and immunofunctional heat-shock proteins in immune dysregulation associated to these disorders.

  • 01 December 2023


    Inez Rogatsky – Epigenomic Control of Macrophage-Driven Inflammation
  • 19 January 2024


    Vignir Helgason – Drug-repurposing for mitochondrial metabolism inhibition in leukaemia
  • 26 January 2024


    Biola M Javierre – Deciphering the 4D epigenomic landscape to understand normal and malignant haematopoiesis


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