Centro Andaluz de Biología Molecular y Medicina Regenerativa
Selected Publications
EMBO Rep Centriolar subdistal appendages promote double-strand break repair through homologous recombination
PLoS Biol Characterization of a novel interaction of the Nup159 nucleoporin with asymmetrically localized spindle pole body proteins and its link with autophagy
Sci Adv SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome
Proc Natl Acad Sci U S A MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
Cell Rep Parental histone distribution and location of the replication obstacle at nascent strands control homologous recombination.

Cintia Roodveldt

Misfolding proteins, molecular chaperones and immune dysregulation in neurodegenerative disease

Protein misfolding diseases, e.g. Parkinson’s, Alzheimer’s and ALS, are incurable neurodegenerative disorders characterized by the aberrant aggregation of specific proteins in the brain or CNS, leading to neuron death. Even the pathogenic mechanisms are still poorly understood, dysregulated immune responses are thought to play a major role. The aim of  our research is to elucidate the roles and molecular mechanisms of misfolding proteins and immunofunctional heat-shock proteins in immune dysregulation associated to these disorders.

  • 06 October 2023


    Corrado Santocanale – Blocking DNA synthesis at origins and at forks: insights into CDC7 kinase targeting drugs using functional genomics approaches
  • 19 October 2023


    Karlene Cimprich – Causes and Consequences of Replication Stress
  • 27 October 2023


    Ulrich Rass – Disease-associated nuclease-helicase DNA2 is an essential gatekeeper to recombination at stalled DNA replication forks from yeast to human


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