Research Groups
Selected Publications
Nat Commun BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Nucleic Acids Res EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.
Nucleic Acids Res Rat1 promotes premature transcription termination at R-loops.
Cell Rep Evolutionary analysis of gene ages across TADs associates chromatin topology with whole-genome duplications.
Staff
Cintia Roodveldt
Immune signaling in neurodegenerative diseases
Protein misfolding diseases, e.g. Parkinson’s, Alzheimer’s and ALS, are incurable neurodegenerative disorders characterized by the aberrant aggregation of specific proteins in the brain or CNS, leading to neuron death. Even the pathogenic mechanisms are still poorly understood, dysregulated immune responses are thought to play a major role. The aim of our research is to elucidate the roles and molecular mechanisms of misfolding proteins and immunofunctional heat-shock proteins in immune dysregulation associated to these disorders.
Seminars
The schedule of Cabimer's 2024-2025 seminars will be published in September, but you can see here the list of this year's seminars.
