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eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Nature Communications. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.
Pablo Huertas
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 13 October 2022
Seminario
Laszlo Nagy – Harnessing the healing power of macrophages: a journey aided by epigenomic and high-dimentional biology approaches - 20 October 2022
Seminario
Gilmar Salgado – HnRNPA1 and G-quadruplexes regulatory role in KRAS expression - 21 October 2022
Seminario
Neil Hunter – Cohesin and Chromosome Segregation in Oocytes: a Goldilocks scenario - 28 October 2022
Seminario
Maite Huarte – Non-coding RNA roles in coordinating DNA replication and its associated stress response
