Centro Andaluz de Biología Molecular y Medicina Regenerativa
News

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Selected Publications

eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.

Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.

Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.

Nature Communications. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.

Nature Communications. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.

Staff

Pablo Huertas

DNA double strand break repair and human disease

Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.

Seminars
  • 29 May 2023

    Seminario

    Kariene Cimprich – Causes and Consequences of Replication Stress
  • 02 June 2023

    Seminario

    Abraham Acevedo – New mechanism and models in ALS
  • 16 June 2023

    Seminario

    Martiijn Luijsterburg – Molecular mechanisms in transcription-coupled DNA repair
  • 30 June 2023

    Seminario

    Malu Martínez-Chantar – The importance of Post-translational control in liver disease

 

Download Conference Series 2022-23