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eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Nature Communications. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
