Nat Commun The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts.
Mol Cell DICER ribonuclease removes harmful R-loops.
EMBO Rep Break-induced RNA-DNA hybrids (BIRDHs) in homologous recombination: friend or foe?.
EMBO Rep Centriolar subdistal appendages promote double-strand break repair through homologous recombination.
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 19 January 2024
SeminarioVignir Helgason – Drug-repurposing for mitochondrial metabolism inhibition in leukaemia
- 26 January 2024
SeminarioBiola M Javierre – Deciphering the 4D epigenomic landscape to understand normal and malignant haematopoiesis