Centro Andaluz de Biología Molecular y Medicina Regenerativa
Selected publications in 2011:

  1. A Subtil-Rodríguez and J C Reyes. 2011. To cross, or not to cross the nucleosome, that is the elongation question. RNA Biology. 8: 389 - 393.

  2. Alvarez-Dolado M, Martínez-Losa M. 2011. Cell fusion and tissue regeneration. Adv Exp Med Biol. 161-75.

  3. Baquié, M, St-Onge, L, Kerr-Conte, J, Cobo-Vuilleumier, N, Lorenzo, PI, Jimenez Moreno, CM, Cederroth, CR, Nef, S, Borot, S, Bosco, D, Wang, H, Marchetti, P, Pattou, F, Wollheim, CB and Gauthier, BR. 2011. The Liver receptor homolog-1 (LRH-1) is expressed in human islets and protects b-cells against stress-induced apoptosis. Hum Mol Genet. 20:2823-33.

  4. Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W, Cocito A, Doksani Y, Klein H, Gomez-Gonzalez B, Aguilera A, Katou Y, Shiragihe K, Foiani M. 2011. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. Cell. 146:233-246.

  5. Chacón PJ, Garcia-Mejias R, Rodriguez-Tebar A. 2011. Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid toxicity. Mol Neurodegeneration. 6:14-24.

  6. Díaz de la Loza MC, Gallardo M, García-Rubio M, Izquierdo A, Herrero E, Aguilera A and Wellinger RE. 2011. Zim17/Tim15 Links Mitochondrial Iron-Sulfur Cluster Biosynthesis to Nuclear Genome Stability. Nucleic Acids Res. 39(14):6002-15.

  7. Dominguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A. 2011. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet. 7(12):e1002386.

  8. Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. 2011. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 11-77.

  9. Erceg S, Moreno-Manzano V, Garita-Hernandez M, Stojkovic M, Bhattacharya SS. 2011. Stem Cells for the Treatment of Cerebellar Related Disorders. Stem Cells. Volume 29, 564-569.

  10. García Jurado G, Llanes D, Moreno A, Soria B, Tejedo JR. 2011. Monoclonal antibody that recognizes a domain on heterogeneous nuclear ribonucleoprotein K and PTB-associated splicing factor. Hybridoma. Vol. 30 (1): 53-59.

  11. García-Gutiérrez P, Juárez-Vicente F, Gallardo-Chamizo F, Charnay P, García-Domínguez M. 2011. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. EMBO Rep. 12: 1018-23.

  12. Garcia-Rubio ML, Aguilera A Garcia-Rubio ML, Aguilera A. 2011. Topical constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. Nucleic Acids Res. doi:10.1093/nar/gkr840.

  13. Gomez-Gonzalez B, Garcia-Rubio M, Bermejo R, Gaillard H, Shirahige K, Marin A, Foiani M, Aguilera A. 2011. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J. 30(15):3106-19 .

  14. Gomez-Gonzalez B, Ruiz JF, Aguilera A Gomez-Gonzalez B, Ruiz JF, Aguilera A Gomez-Gonzalez B, Ruiz JF, Aguilera A Gomez-Gonzalez B, Ruiz JF, Aguilera A Gomez-Gonzalez B, Ruiz JF, Aguilera A. 2011. Genetic and molecular analysis of mitotic recombination in saccharomyces cerevisiae. DNA Recombination Methods in Molecular Biology. 745:151-172.

  15. Gonzalez-Aguilera C, Tous C, Babiano R, De la Cruz J, Luna R, Aguilera A. 2011. Nab 2 functions in the metabolism of RNA driven by polymerases II and III. Mol Biol Cell. 22(15):2729-40 .

  16. Hohl, M Kwon, Y Muñoz Galvan, S Xue, X Tous, C Aguilera, AP Sung, P Petrini, JHJ. 2011. The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol. doi: 10.1038/nsmb.2116.

  17. Hu He, KH, Lorenzo, PI, Brun, T, Jimenez Moreno, CM, Aeberhard, D, Cornu, M, Thorel, F, Gjinovci, A, Thorens, B, Herrera, PL, Meda, P, Wollheim, CB, and Gauthier, BR. 2011. In vivo conditional Pax4 overexpression in mature islet beta cells prevents stress-induced hyperglycemia in mice. Diabetes. 60:1705-1715.

  18. Hurtado L, Caballero C, Gavilan MP, Cardenas J, Bornens M, Rios RM. 2011. Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis. J Cell Biol. 917-33.

  19. Jimeno S, Tous C, García-Rubio ML, Ranes M, González-Aguilera C, Marín A, Aguilera A. 2011. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Bio. 31(4):674-85.

  20. Kai Hui Hu He, Petra I Lorenzo, Thierry Brun, Carmen M Jimenez Moreno, Deborah Aeberhard, Jorge Vallejo Ortega, Marion Cornu, Fabrizio Thorel, Asllan Gjinovci, Bernard Thorens, Pedro L Herrera, Paolo Meda, Claes B Wollheim and Benoit R Gauthier. 2011. In Vivo Conditional Pax4 Overexpression in Mature Isle ß-Cells Prevents Stress-Induced Hyperglycemia in Mice. Diabetes. 2011 Apr 26.

  21. Kierszenbaum AL, Rivkin E, Tres LL, Yoder BK, Haycraft CJ, Bornens M, Rios RM. 2011. GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail. Dev Dyn. 723-36.

  22. Kirkpatrick CL, Wiederkehr A, Baquie M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. 2011. Hepatic nuclear factor 1a (HNF-1a) dysfunction downregulates X-box binding protein 1 (Xbp-1) and sensitizes b-cells to endoplasmic reticulum stress. J Biol Chem. 286(37):32300-12.

  23. León-Quinto Trinidad, Simón Miguel A, Sánchez Ángel, Martín Francisco, Soria Bernat. 2011. Cryobanking the genetic diversity in the critically endangered Iberian lynx (Lynx pardinus) from skin biopsies Investigating the cryopreservation and culture ability of highly valuable explants and cells. Cryobiology. Vol. 62 (2): 145-151.

  24. Lorenzo, PI, Jimenez Moreno, CM, Delgado, I, Cobo-Vuilleumier, N, Meier, R, Gomez-Izquierdo, L, Berney, T, Garcia-Carbonero, R, Rojas, A and Gauthier, BR. 2011. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. Hist Cell Biol. 136(5):595-607.

  25. Luna R, Rondon AG, Aguilera A. 2011. New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim Biophys Acta. doi:10.1038/emboj.2012.10.

  26. Marta Clemente-Ruiz, Roman Gonzalez-Prieto, Felix Prado. 2011. Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks. PLOS Genetics. 7-11:e1002376.

  27. Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. 2011. Yeast Sen1 helicase protects the genome from transcription-associated instability. Mol Cell. 41(1):21-32.

  28. Moreno CM, Lorenzo PI, Delgado I, Cobo-Vuilleumier N, Gomez-Izquierdo L, Garcia-Carbonero R, Rojas A, Gauthier BR. 2011. Pax8 Detection in Well-Differentiated Pancreatic Endocrine Tumors: How Reliable is it?. Am J Surg Pathol. 35(12):1906-8.

  29. Moriel-Carretero M, Tous C, Aguilera A. 2011. Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1. Proc Natl Sci USA. 108(37):15300-5.

  30. Qvist P, Huertas P, Jimeno S, Nyegaard M, Hassan MJ, Jackson SP, Børglum AD. 2011. CtIP Mutations Cause Seckel and Jawad Syndromes. PLOS Genetics. 7(10):e1002310. Epub 2011 Oct 6..

  31. Recio JS, Alvarez-Dolado M, Díaz D, Baltanás FC, Piquer-Gil M, Alonso JR, Weruaga E. 2011. Bone marrow contributes simultaneously to different neural types in the central nervous system through different mechanisms of plasticity. Cell Transplant. 12(4):e1950-e1961.

  32. Ruiz JF, Gómez-González B, Aguilera A. 2011. AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. PLoS Genet. 7(2):e1002009.

  33. Ruiz-Salmeron R, de la Cuesta-Diaz A, Constantino-Bermejo M, Pérez-Camacho I, Marcos-Sánchez F, Hmadcha A, Soria B. 2011. Angiographic demonstration of Neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischaemia. Cell Transplantation. Apr 20th.

  34. S Farrona, L Hurtado, R March-Díaz, RJ Schmitz, F J Florencio, F Turck, R Amasino and JC Reyes. 2011. Brahma is required for proper expression of the floral repressor FLC in Arabidopsis. PLoS One. 6(3):e17997.

  35. Simon-Areces J, Dopazo A, Dettenhofer M, Rodriguez-Tebar A, Garcia-Segura LM, Arevalo MA. 2011. Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons. Plos One. 6:e21825.

  36. Tous C, Rondón AG, García-Rubio M, González-Aguilera C, Luna R, Aguilera A. 2011. A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J. 30(10):1953-64.

  37. Valerio-Santiago M, Monje-Casas F. 2011. Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function. The Journal of Cell Biology. 192(4):599-614.