Centro Andaluz de Biología Molecular y Medicina Regenerativa
Selected publications in 2021:

  1. Aguilera Y, Mellado-Damas N, Olmedo-Moreno L, López V, Panadero-Morón C, Benito M, Guerrero-Cázares H, Márquez-Vega C, Martín-Montalvo A, Capilla-González V. 2021. Preclinical Safety Evaluation of Intranasally Delivered Human Mesenchymal Stem Cells in Juvenile Mice. Cancers (Basel). 13(5):1169 .

  2. Álvarez-Amor L, Sierra AL, Cárdenas A, López-Bermudo L, López-Beas J, Andújar E, Pérez-Alegre M, Gallego-Durán R, Varela LM, Martin-Montalvo A, Berná G, Rojas A, Robles-Frías MJ, Hmadcha A, Romero-Gómez M, Kleemann R, Martín F. 2021. Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-Leiden mice without attenuation of steatohepatitis. Sci Rep. 11(1):8250 .

  3. Balestra FR, Domínguez-Calvo A, Wolf B, Busso C, Buff A, Averink T, Lipsanen-Nyman M, Huertas P, Ríos RM, Gönczy P. 2021. TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin. Elife. 25;10:e62640.

  4. Bayona-Feliu A, Barroso S, Muñoz S, Aguilera A. 2021. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts. Nat Genet. 53(7):1050-1063 .

  5. Bodineau C, Tomé M, Courtois S, Costa ASH, Sciacovelli M, Rousseau B, Richard E, Vacher P, Parejo-Pérez C, Bessede E, Varon C, Soubeyran P, Frezza C, Murdoch PDS, Villar VH, Durán RV. 2021. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis. Nat Commun. 12(1):4814 .

  6. Buono L, Corbacho J, Naranjo S, Almuedo-Castillo M, Moreno-Marmol T, de la Cerda B, Sanbria-Reinoso E, Polvillo R, Díaz-Corrales FJ, Bogdanovic O, Bovolenta P, Martínez-Morales JR. 2021. Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nat Commun. 12(1):3866 .

  7. Cabello-Lobato MJ, González-Garrido C, Cano-Linares MI, Wong RP, Yáñez-Vílchez A, Morillo-Huesca M, Roldán-Romero JM, Vicioso M, González-Prieto R, Ulrich HD, Prado F. 2021. Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions. Cell Reports. 36(4):109440 .

  8. Cañibano-Hernández A, Valdes-Sanchez L, Garcia-Delgado AB, Ponte-Zúñiga B, Diaz-Corrales FJ, de la Cerda B. 2021. Generation of the human iPSC line ESi082-A from a patient with macular dystrophy associated to mutations in the CRB1 gene. Stem Cell Res. 53:102301 .

  9. Cano-Linares MI, Yáñez-Vilches A, García-Rodríguez N, Barrientos-Moreno M, González-Prieto R, San-Segundo P, Ulrich HD, Prado F. 2021. Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance. EMBO Reports. 22(1):e50410 .

  10. Chacin E, Bansal P, Reusswig KU, Diaz-Santin LM, Ortega P, Vizjak P, Gómez-González B, Müller-Planitz F, Aguilera A, Pfander B, Cheung ACM, Kurat CF. 2021. A CDK-regulated chromatin segregase promoting chromosome replication. Nat Commun. 12(1):5224 .

  11. Correa-Vázquez JF, Juárez-Vicente F, García-Gutiérrez P, Barysch SV, Melchior F, García-Domínguez M. 2021. The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis. Cell Death Dis. 12(4):305. .

  12. Dagg RA, Zonderland G, Lombardi EP, Rossetti GG, Groelly FJ, Barroso S, Tacconi EMC, Wright B, Lockstone H, Aguilera A, Halazonetis TD, Tarsounas M. 2021. A transcription-based mechanism for oncogenic ?-catenin-induced lethality in BRCA1/2-deficient cells. Nat Commun. 13;12(1):4919 .

  13. Gabasa M, Radisky ES, Ikemori R, Bertolini G, Arshakyan M, Hockla A, Duch P, Rondinone O, Llorente A, Maqueda M, Davalos A, Gavilán E, Perera A, Ramírez J, Gascón P, Reguart N, Roz L, Radisky DC, Alcaraz J. 2021. MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. Cancer Lett. S0304-3835(21)00052-5 .

  14. Gallego P, Luque-Sierra A, Falcon G, Carbonero P, Grande L, Bautista JD, Martín F, Del Campo JA. 2021. White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice. Foods. 10(8):1788 .

  15. García-Gutiérrez P, García-Domínguez M. 2021. BETting on a Transcriptional Deficit as the Main Cause for Cornelia de Lange Syndrome. Front Mol Biosci. 8:709232 .

  16. Garcia-Jimenez MJ, Gil-Caballero S, Maza S, Corzana F, Juarez-Vicente F, Miles JR, Sakamoto K, Kadomatsu K, Dominguez-García M, de Paz JL, Nieto PM. 2021. Midkine Interaction with Chondroitin Sulfate Model Synthetic Tetrasaccharides and Their Mimetics: The Role of Aromatic Interactions. CHEMISTRY-A EUROPEAN JOURNAL. 27(48):12395-12409 .

  17. Gauthier BR, Comaills V. 2021. Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation. Int J Mol Sci. 22(14):7281 .

  18. Gea-Botella S, Agulló L, Martí N, Martínez-Madrid MC, Lizama V, Martín-Bermudo F, Berná G, Saura D, Valero M. 2021. Carotenoids from persimmon juice processing. Food Res Int. 141:109882.

  19. Gómez-González B, Aguilera A. 2021. Origin matters: spontaneous DNA-RNA hybrids do not form in trans as a source of genome instability. Current Genet. 63: 93–97 .

  20. Gómez-González B, Sessa G, Carreira A, Aguilera A. 2021. A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin. Mol Cell Oncol. 8(3):1910474 .

  21. Herrero-Ruiz A, Martínez-García PM, Terrón-Bautista J, Millán-Zambrano G, Lieberman JA, Jimeno-González S, Cortés-Ledesma F. 2021. Topoisomerase IIa represses transcription by enforcing promoter-proximal pausing. Cell Reports. 35(2):108977 .

  22. Jimeno S, Balestra FR, Huertas P. 2021. The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair. Front Mol Biosci. 8:664872 .

  23. Jimeno S, Prados-Carvajal R, Fernández-Ávila MJ, Silva S, Silvestris DA, Endara-Coll M, Rodríguez-Real G, Domingo-Prim J, Mejías-Navarro F, Romero-Franco A, Jimeno-González S, Barroso S, Cesarini V, Aguilera A, Gallo A, Visa N, Huertas P. 2021. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair. Nat Commun. 12(1):5512.

  24. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1. Autophagy. 17(1):1-382 .

  25. Kosar M, Giannattasio M, Piccini D, Maya-Mendoza A, García-Benítez F, Bartkova J, Barroso SI, Gaillard H, Martini E, Restuccia U, Ramirez-Otero MA, Garre M, Verga E, Andújar-Sánchez M, Maynard S, Hodny Z, Costanzo V, Kumar A, Bachi A, Aguilera A, Bartek J, Foiani M. 2021. The human nucleoporin Tpr protects cells from RNA-mediated replication stress. Nat Commun. 12(1):3937 .

  26. Lara-Ureña N, García-Domínguez M. 2021. Relevance of BET Family Proteins in SARS-CoV-2 Infection. Biomolecules. 11(8):1126 .

  27. Leal-Lasarte M, Mannini B, Chiti F, Vendruscolo M, Dobson CM, Roodveldt C, Pozo D. 2021. Distinct responses of human peripheral blood cells to different misfolded protein oligomers. Immunology. Ahead of print .

  28. Lebrón JA, López-Cornejo P, García-Dionisio E, Huertas P, García-Calderón M, Moyá ML, Ostos FJ, López-López M. 2021. Cationic Single-Chained Surfactants with a Functional Group at the End of the Hydrophobic Tail DNA Compacting Efficiency. Pharmaceutics. 13(4):589 .

  29. Lebrón JA, López-López M, García-Calderón CB, V Rosado I, Balestra FR, Huertas P, Rodik RV, Kalchenko VI, Bernal E, Moyá ML, López-Cornejo P, Ostos FJ. 2021. Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery. Pharmaceutics. 13(8):1250 .

  30. López-Bermudo L, Gómez-Landero LA. 2021. Healthy Habits in Firefighters: Assessment in Shift Days Versus Days Off. J Occup Environ Med. 63(9):e580-e585.

  31. Lorenzo PI, Cobo-Vuilleumier N, Martín-Vázquez E, López-Noriega L, Gauthier BR. 2021. Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?. Int J Mol Sci. 22(8):4239 .

  32. Martínez-García PM, García-Torres M, Divina F, Terrón-Bautista J, Delgado-Sainz I, Gómez-Vela F, Cortés-Ledesma F. 2021. Genome-wide prediction of topoisomerase IIB binding by architectural factors and chromatin accessibility. PLoS Comput Biol. 17(1):e1007814.

  33. Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. 2021. Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia. Molecular Oncology. Ahead of print .

  34. Ortega P, Gómez-González B, Aguilera A. 2021. Heterogeneity of DNA damage incidence and repair in different chromatin contexts. DNA Repair (Amst). Ahead of print .

  35. Ortega P, Mérida-Cerro JA, Rondón AG, Gómez-González B, Aguilera A. 2021. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination. Elife. e69881 .

  36. Payán-Bravo L, Fontalva S, Peñate X, Cases I, Guerrero-Martínez JA, Pareja-Sánchez Y, Odriozola-Gil Y, Lara E, Jimeno-González S, Suñé C, Muñoz-Centeno MC, Reyes JC, Chávez S. 2021. Human prefoldin modulates co-transcriptional pre-mRNA splicing. Nucleic Acids Res. 49(11):6267-6280 .

  37. Petra I Lorenzo, Eugenia Martin Vazquez, Livia López-Noriega, Esther Fuente-Martín, José M Mellado-Gil, Jaime M Franco, Nadia Cobo-Vuilleumier, José A Guerrero Martínez, Silvana Y Romero-Zerbo, Jesús A Perez-Cabello, Sabrina Rivero Canalejo, Antonio Campos-Caro, Christian Claude Lachaud, Alejandra Crespo Barreda, Manuel Aguilar-Diosdado, Eduardo García Fuentes, Alejandro Martin-Montalvo, Manuel Álvarez Dolado, Franz Martin, Gemma Rojo-Martinez, David Pozo, Francisco J Bérmudez-Silva, Valentine Comaills, José C Reyes , Benoit R Gauthier. 2021. The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity. Theranostics. 11(14):6983-7004. .

  38. Petryk N, Reverón-Gómez N, González-Aguilera C, Dalby M, Andersson R, Groth A. 2021. Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq. Nat protocol. 16(9):4446-4493 .

  39. Rivero S, Rodríguez-Real G, Marín I, Huertas P. 2021. MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair. FEBS Open Bio. 11(3):622-632 .

  40. Rivero-Rodríguez F, Díaz-Quintana A, Velázquez-Cruz A, González-Arzola K, Gavilan MP, Velázquez-Campoy A, Ríos RM, De la Rosa MA, Díaz-Moreno I. 2021. Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c. Redox Biol. 43:101967 .

  41. Rosell-Valle C, Martínez-Losa M, Matas-Rico E, Castilla-Ortega E, Zambrana-Infantes E, Gómez-Conde AI, Sánchez-Salido L, Ladrón de Guevara-Miranda D, Pedraza C, Serrano-Castro PJ, Chun J, Rodríguez de Fonseca F, Álvarez-Dolado M, Santín LJ, Estivill-Torrús G. 2021. GABAergic deficits in absence of LPA 1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus. Brain Struct Funct. 226(5):1479-1495 .

  42. Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, et all. 2021. Genetic insights into biological mechanisms governing human ovarian . Nature. 596(7872):393-397 .

  43. Sabido-Bozo S, Perez-Linero AM, Manzano-Lopez J, Rodriguez-Gallardo S, Aguilera-Romero A, Cortes-Gomez A, Lopez S, Wellinger RE, Muñiz M. 2021. The p24 Complex Contributes to Specify Arf1 for COPI Coat Selection. Int J Mol Sci. 22(1):E423.

  44. Safari M, Litman T, Robey R, Aguilera A, Chakraborty AR, Reinhold W, Basseville A, Petrukhin L, Scotto L, O'Connor OA, Pommier Y, Fojo AT, Bates SE. 2021. R-loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin. Mol Cancer Res. 19(8):1361-1374 .

  45. San Martin-Alonso M, Soler-Oliva ME, García-Rubio M, García-Muse T, Aguilera A. 2021. Harmful R-loops are prevented via different cell cycle-specific mechanisms. Nat Commun. 12(1):4451 .

  46. Sanchez-Castro EE, Pajuelo-Reyes C, Tejedo R, Soria-Juan B, Tapia-Limonchi R, Andreu E, Hitos AB, Martin F, Cahuana GM, Guerra-Duarte C, de Assis TCS, Bedoya FJ, Soria B, Chávez-Olórtegui C, Tejedo JR. 2021. Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming. Front Immunol. 11:609961 .

  47. Santos-Rosa H, Millán-Zambrano G, Han N, Leonardi T, Klimontova M, Nasiscionyte S, Pandolfini L, Tzelepis K, Bartke T, Kouzarides T. 2021. Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication. Moll cell. 81(13):2793-2807.e8.  .

  48. Sessa G, Gómez-González B, Silva S, Pérez-Calero C, Beaurepere R, Barroso S, Martineau S, Martin C, Ehlén Å, Martínez JS, Lombard B, Loew D, Vagner S, Aguilera A, Carreira A. 2021. BRCA2 promotes R-loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination. EMBO JOURNAL. 40(7):e106018 .

  49. Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML. 2021. Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leuk. J Hepatol. Ahead of print .

  50. Vakilian M, Ghaedi K. 2021. A new hypothetical model for pancreatic development based on change in the cell division orientation. Gene. Ahead of print .