Nature Communications. The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
Nature Genetics. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts.
Theranostics. The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity.
The EMBO Journal. BRCA2 promotes R‐loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination.
eLife. TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
Ralf Erik Wellinger
Mitochondrial Plasticity and Replication
The genetic material including mitochondrial, telomeric and nucleolar (ribosomal) DNA is constantly exposed to endogenous or exogenous stress. We are particularly interested in the factors and molecular pathways causing genome instability, disease and premature aging.