PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.
Mol. Ther. PDGF restores the defective phenotype of adipose-derived mesenchymal stromal cells from diabetic patients.
EMBO Rep. The dual role of the centrosome in organizing the microtubule network in interphase.
Genes Dev. Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 18 January 2019
SeminarioRoger Gomis – Tissue-specific and time-dependent mechanisms of metastasis
- 25 January 2019
SeminarioThanos Halazonetis -DNA replication stress and cancer