Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.
PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.
Mol. Ther. PDGF restores the defective phenotype of adipose-derived mesenchymal stromal cells from diabetic patients.
EMBO Rep. The dual role of the centrosome in organizing the microtubule network in interphase.
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 01 February 2019
SeminarioClaudio de Virgilio – Regulation of TORC1 by Amino Acids: a Central Role for Rag GTPases Within the EGO Complex
- 06 February 2019
SeminarioJosé Ignacio Martí-Subero – Reference epigenomes and 3D genomes in normal and neoplastic B cells
- 08 February 2019
SeminarioThanos Halazonetis -DNA replication stress and cancer