Nature Cell Biology. Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan.
Nucleic Acids Res. The Nup84 complex coordinates the DNA damage response to warrant genome integrity.
Cell Rep. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.
Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.
PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Alejandro Martín-Montalvo Sánchez
Metabolic interventions for healthy aging
During the last decades, life expectancy has increased considerably, but in many cases this increase in longevity is not accompanied by a good quality of life. Our line of research is focused on the elucidation of the molecular mechanisms involved in the development of age-related pathologies and the definition of new pharmacological interventions aiming to maintain optimal health during this phase of life.