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Nucleic Acids Res. The Nup84 complex coordinates the DNA damage response to warrant genome integrity.
Cell Rep. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.
Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.
PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
