PNAS. Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.
EMBO J. Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.
Curr Biol. Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation.
Cell division control
Advancing in our knowledge about cell division is essential in order to better understand the development of diseases that arise as a consequence of an incorrect regulation of this process, such as cancer. Our group is particularly interested in unveiling the signaling pathways that orchestrate cell cycle progression, as well as in deciphering the molecular mechanisms by which the main cellular checkpoints regulate this process to ensure the fidelity of chromosome segregation.
- 19 January 2018
SeminarioXosé J. Bustelo – Role of Vav oncoproteins in cancer: from mice to humans and viceversa
- 26 January 2018
SeminarioJuan M. Vaquerizas – Chromatin architecture in development and disease