Centro Andaluz de Biología Molecular y Medicina Regenerativa
News

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Selected Publications

eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.

Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.

Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.

Nature Communications. The human nucleoporin Tpr protects cells from RNA-mediated replication stress.

Nature Genetics. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts.

Staff

Cintia Roodveldt

Misfolding proteins, molecular chaperones and immune dysregulation in neurodegenerative disease

Protein misfolding diseases, e.g. Parkinson’s, Alzheimer’s and ALS, are incurable neurodegenerative disorders characterized by the aberrant aggregation of specific proteins in the brain or CNS, leading to neuron death. Even the pathogenic mechanisms are still poorly understood, dysregulated immune responses are thought to play a major role. The aim of  our research is to elucidate the roles and molecular mechanisms of misfolding proteins and immunofunctional heat-shock proteins in immune dysregulation associated to these disorders.

Seminars
  • 29 October 2021

    Seminario

    Daniel Rico – Chromatin dynamics in cancer and evolution
  • 26 November 2021

    Seminario

    Jörn Dengjel – Protein kinases and phosphatases regulating autophagy
  • 03 December 2021

    Seminario

    Luis Toledo – A new function for the TRESLIN-MTBP complex in human cells: regulation of the S/G2 transition

 

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