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eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
Nature Genetics. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts.
David Pozo Perez
Cellular and Molecular Neuroimmunology
Not so long ago, immune responses in neurodegeneration were regarded as rare birds in the field of clinical neurology. Today, they are increasingly moving toward centre stage. The rationale behind includes the recognition that most of the relevant immune molecules are produced within the brain, that microglia among other immune-competent cells are proficient tools shaping neuronal circuitry and fate, and that systemic immune responses affect brain function in health and disease. Our group is interested in how the immune system inside the central nervous system is finely regulated at molecular and cellular levels. We are focused on the role of neuro-immune interactions in Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS).
