Nature Communications. TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains.
eLife. Polo-like kinase acts as a molecular timer that safeguards the asymmetric fate of spindle microtubule-organizing centers.
eLife. Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independet manner.
Molecular Cell. Looping the (R) Loop in DSB Repair via RNA Methylation
Genes Dev. UAP56/DDX39B Is a Major Cotranscriptional RNA-DNA Helicase That Unwinds Harmful R Loops Genome-Wide.
Alejandro Martín-Montalvo Sánchez
Metabolic interventions for healthy aging
During the last decades, life expectancy has increased considerably, but in many cases this increase in longevity is not accompanied by a good quality of life. Our line of research is focused on the elucidation of the molecular mechanisms involved in the development of age-related pathologies and the definition of new pharmacological interventions aiming to maintain optimal health during this phase of life.
- 29 January 2021
SeminarioAntonio Zorzano – Mitochondrial dynamics and metabolic disorders
- 05 February 2021
SeminarioGermaine Escames – Can melatonin reduce the severity of COVID-19 pandemic?
- 19 February 2021
SeminarioDavid Hodson – Understanding beta cell heterogeneity from the single protein to the intact islet