Centro Andaluz de Biología Molecular y Medicina Regenerativa
News

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Selected Publications

Nature Cell Biology. Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan.

Nucleic Acids Res. The Nup84 complex coordinates the DNA damage response to warrant genome integrity.

Cell Rep. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.

Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.

PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.

Staff

Tatiana García Muse

DNA damage response during meiosis

Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.

Seminars
  • 13 December 2019

    Seminario

    Álvaro Rada-Iglesias – Compatability between genes and enhancers in development and congenital disease
  • 17 January 2020

    Seminario

    Pere Santamaria – Nanomedicines for the treatment of chronic inflammation
  • 31 January 2020

    Seminario

    Ritwick Sawarkar – Transcriptional response to proteotoxic stress in mammalian cells

 

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