eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
Nature Genetics. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts.
Cell division control
Advancing in our knowledge about cell division is essential in order to better understand the development of diseases that arise as a consequence of an incorrect regulation of this process, such as cancer. Our group is particularly interested in unveiling the signaling pathways that orchestrate cell cycle progression, as well as in deciphering the molecular mechanisms by which the main cellular checkpoints regulate this process to ensure the fidelity of chromosome segregation.