Cell Rep. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.
Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.
PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.
Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.
EMBO Rep. The dual role of the centrosome in organizing the microtubule network in interphase.
David Pozo Perez
Cellular and Molecular Neuroimmunology
Not so long ago, immune responses in neurodegeneration were regarded as rare birds in the field of clinical neurology. Today, they are increasingly moving toward centre stage. The rationale behind includes the recognition that most of the relevant immune molecules are produced within the brain, that microglia among other immune-competent cells are proficient tools shaping neuronal circuitry and fate, and that systemic immune responses affect brain function in health and disease. Our group is interested in how the immune system inside the central nervous system is finely regulated at molecular and cellular levels. We are focused on the role of neuro-immune interactions in Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS).