eLife. Polo-like kinase acts as a molecular timer that safeguards the asymmetric fate of spindle microtubule-organizing centers.
eLife. Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independet manner.
Molecular Cell. Looping the (R) Loop in DSB Repair via RNA Methylation
Genes Dev. UAP56/DDX39B Is a Major Cotranscriptional RNA-DNA Helicase That Unwinds Harmful R Loops Genome-Wide.
Nature Cell Biology. Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan.
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
- 04 December 2020
SeminarioJoseph Yeeles – The Eukaryotic Replisome: Structure and Mechanism
- 15 January 2021
SeminarioClaus Azzalin – Alternative Lengthening of Telomeres in cancer: triggers and alleviators
- 22 January 2021
SeminarioAndrés Clemente – Genome-wide analysis of DNA repair at single-nucleotide resolution
- 29 January 2021
SeminarioAntonio Zorzano – Mitochondrial dynamics and metabolic disorders
- 05 February 2021
SeminarioGermaine Escames – Can melatonin reduce the severity of COVID-19 pandemic?