Investigadores de US y Cabimer estudian posibles alteraciones en el ADN implicadas en el cáncer
Research Groups
Core Facilities
Selected Publications
Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.
Mol. Ther. PDGF restores the defective phenotype of adipose-derived mesenchymal stromal cells from diabetic patients.
EMBO Rep. The dual role of the centrosome in organizing the microtubule network in interphase.
Genes Dev. Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.
PLoS Genet. Histone depletion prevents telomere fusions in pre-senescent cells.
Staff
Tatiana García Muse
DNA damage response during meiosis
Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents. Without proper repair the resulting DNA damages would lead to alteration of genomic structure thus affecting the faithful transmission of genetic information. In addition, defects during meiosis lead to aneuploidy, an extreme kind of genetic instability associated with fertility problems, miscarriages and mental retardation syndromes. I use the Caenorhabditis elegans model organism to address the impact of DNA damage on genome stability in meiotic cells.
Seminars
- 05 October 2018
Seminario
Amanda Sierra – Clearing the corpses: microglial phagocytosis from neurodegeneration to neurogenesis - 11 October 2018
Seminario
Rafael Casellas – How nuclear architecture regulates gene expression - 19 October 2018
Seminario
Tiziana Brevini – Epigenetic mechanisms and bio-mechanical effectors controlling cell fate - 26 October 2018
Seminario
Pere Roca-Cusachs – Sensing the matrix: transducing mechanical signals from integrins to the nucleus
