eLife. DNA-RNA hybrids at DSBs interfere with repair by homologous recombination.
Nature Communications. Harmful R-loops are prevented via different cell cycle-specific mechanisms.
Nature Communications. Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Nature Communications. The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
Nature Genetics. The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts.
DNA double strand break repair and human disease
Our lab focuses in the understanding on how cells deal with broken chromosomes. Indeed, unbalanced repair of DNA breaks lead to the accumulation of genomic alterations, a phenomenon known as genomic instability that is at the root of the development of several diseases, including cancer and some rare syndromes.
- 29 October 2021
SeminarioDaniel Rico – Chromatin dynamics in cancer and evolution
- 26 November 2021
SeminarioJörn Dengjel – Protein kinases and phosphatases regulating autophagy
- 03 December 2021
SeminarioLuis Toledo – A new function for the TRESLIN-MTBP complex in human cells: regulation of the S/G2 transition