Centro Andaluz de Biología Molecular y Medicina Regenerativa
News

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Selected Publications

Nucleic Acids Res. The Nup84 complex coordinates the DNA damage response to warrant genome integrity.

Cell Rep. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs.

Diabetes. Transient PAX8 Expression in Islets During Pregnancy Correlates With Beta Cell Survival Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.

PNAS. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.

Cell Reports. The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.

Staff

Cintia Roodveldt

Misfolding proteins, molecular chaperones and immune dysregulation in neurodegenerative disease

Protein misfolding diseases, e.g. Parkinson’s, Alzheimer’s and ALS, are incurable neurodegenerative disorders characterized by the aberrant aggregation of specific proteins in the brain or CNS, leading to neuron death. Even the pathogenic mechanisms are still poorly understood, dysregulated immune responses are thought to play a major role. The aim of  our research is to elucidate the roles and molecular mechanisms of misfolding proteins and immunofunctional heat-shock proteins in immune dysregulation associated to these disorders.

Seminars
  • 07 June 2019

    Seminario

    Tanya Paull – Mechanisms of DNA repair in eukaryotic cells
  • 14 June 2019

    Seminario

    Ian J. Holt – Mitochondrial DNA: In The Loop

 

Download Conference Series 2018-19