Prof. Romano Regazzi
Université de Lausanne, Switzerland

Emerging roles of microRNAs in the control of pancreatic beta cell functions

Insulin release from pancreatic beta cells plays a central role in blood glucose homeostasis. In animal models, defective insulin release and development of diabetes mellitus are associated with alterations in the level of several beta cell microRNAs, a novel class of gene regulators. Modulation of the level of these microRNAs elicits changes in gene expression that lead to defective insulin release and beta cell apoptosis mimicking the conditions observed in prediabetic stages. These findings suggest that microRNAs may play an important role in the development of the disease.

28/10/11   12:00h
Cabimer, Salón de actos

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