Prof. Alberto R. Kornblihtt
IFIBYNE-CONICET, Universidad de Buenos Aires, Argentina

Chromatin and transcription regulate alternative splicing

Alternative pre-mRNA splicing is the major contributor to protein diversity in eukaryotic cells. We will discuss the mechanisms that couple RNA polymerase II transcription to alternative splicing, which include regulation of transcriptional elongation, recruitment of splicing factors to the transcription machinery and histone modifications affecting chromatin structure.

20/10/11   12:00h
Cabimer, Salón de actos

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